Dear ITK Users and Developers,<br><br> In deformable image registration, it is very common to find the image gradient at non-grid positions. For example, to obtain the driving force by taking the derivative of SSD similarity measure. I am wondering how this procedure is implemented in ITK. I used to construct a continuous image based on Bspline model and then find the derivitive at non-grid positions. However, I recently found a MATLAB code which resamples the image based on the current deformation field and then find the gradient at the resampled image. In this way, there is no need to find the gradient at non-grid positions. Afterwards, the gradient information is used to construct the update of the deformation field and the new deformation field is obtained by ADDING the update to the original deformation field. Is this a common practice to implement deformable image registration algorithms like demons, fluid, and FFD in ITK? Any response is appreciated.<br>
<br>Chen <br>