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<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>Dear
list-subscribers,</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT face=Arial><FONT color=#0000ff><FONT
size=2>We are proud to announce a new release of elastix: elastix 4.2
!</FONT></FONT></FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
face=Arial><FONT color=#0000ff size=2>Elastix is a software package for image
registration, based on the ITK. The software consists of a collection of
algorithms that are commonly used to solve medical image registration problems.
The modular design of elastix allows the user to quickly configure, test, and
compare different registration methods for a specific application. In addition
to the existing ITK image registration classes, elastix implements new
functionality. The most important enhancements
are</FONT></FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN
class=343342415-18082009></SPAN></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><SPAN
class=343342415-18082009></SPAN></SPAN><SPAN class=250084514-18082009><SPAN
class=343342415-18082009><FONT face=Arial><FONT color=#0000ff><FONT size=2>- A
modular framework for sampling
strategies.</FONT></FONT></FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
color=#0000ff size=2 face=Arial>- More optimisers: Kiefer-Wolfowitz,
Robbins-Monro, adaptive </FONT></SPAN></SPAN><SPAN
class=250084514-18082009><SPAN class=343342415-18082009><FONT color=#0000ff
size=2 face=Arial>stochastic gradient descent, evolutionary
strategy.</FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
color=#0000ff size=2 face=Arial>- Complete rework of existing ITK optimisers,
adding more user control </FONT></SPAN></SPAN><SPAN
class=250084514-18082009><SPAN class=343342415-18082009><FONT color=#0000ff
size=2 face=Arial>and better error handling: quasi-Newton, nonlinear conjugate
gradient.</FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
color=#0000ff size=2 face=Arial>- </FONT></SPAN></SPAN><SPAN
class=250084514-18082009><SPAN class=343342415-18082009><FONT color=#0000ff
size=2 face=Arial>Several new or more flexible cost functions: (normalised)
mutual </FONT><FONT color=#0000ff size=2 face=Arial>information, implemented
with Parzen windowing similar to [45], multifeature </FONT><FONT color=#0000ff
size=2 face=Arial>$B&A(B-mutual information, bending energy penalty term, rigidity
</FONT><FONT color=#0000ff size=2 face=Arial>penalty
term.</FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
face=Arial><FONT color=#0000ff size=2>- The ability to concatenate any number of
geometric transformations.</FONT></FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
face=Arial><FONT color=#0000ff size=2>- The transformations support computation
of not only $B"_(BT/$B"_&L(B, but also </FONT></FONT><FONT color=#0000ff size=2
face=Arial>of spatial derivatives $B"_(BT/$B"_(Bx and $B"_(B2T/$B"_(Bx2, and their derivatives to
</FONT><FONT color=#0000ff size=2 face=Arial>$B&L(B, frequently required for the
computation of regularisation terms. Additionally, </FONT><FONT color=#0000ff
size=2 face=Arial>the compact support of certain transformations is integrated
</FONT><FONT color=#0000ff size=2 face=Arial>more
generally.</FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
face=Arial><FONT color=#0000ff size=2>- Linear combinations of cost functions,
instead of just a single cost </FONT></FONT><FONT color=#0000ff size=2
face=Arial>function.</FONT></SPAN></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><SPAN class=343342415-18082009><FONT
color=#0000ff size=2 face=Arial></FONT></SPAN></SPAN> </DIV>
<DIV><FONT face=Arial><FONT color=#0000ff><FONT size=2><SPAN
class=250084514-18082009><SPAN
class=343342415-18082009> </SPAN></SPAN><SPAN
class=250084514-18082009>Elastix can be downloaded<SPAN
class=343342415-18082009> </SPAN>from the website<SPAN
class=343342415-18082009>, under the very open BSD license,
see</SPAN>:</SPAN></FONT></FONT></FONT></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial> </FONT><A href="http://elastix.isi.uu.nl/"><FONT
size=2 face=Arial>http://elastix.isi.uu.nl/</FONT></A></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>We
have updated quite some components in this new release<SPAN
class=343342415-18082009> compared to elastix 4.1</SPAN>, and also added a few.
The most important changes are:</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>- The
implementation of spatial derivatives in all transform classes. This enables the
computation of many regularisation (penalty) terms in a general
way.</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial>- A general way of dealing with sparse Jacobians, so
that for example much less B-spline specific code is needed
anymore.</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>- The
adaptive stochastic gradient descent (ASGD) optimization routine is now usable
for much larger registration problems. (It used to crash when the number of
parameters was larger than 10 000.)</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>- We
added the following components: WeightedCombinationTransform,
SplineKernelTransform (which implements a ThinPlateSpline, ElasticBodySpline,
VolumeSpline, and an ElasticBodyReciprocalSpline), TransformRigidityPenalty,
TransformBendingEnergyPenalty, DisplacementMagnitudePenalty.</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>A more
complete list of changes can be found at the website:</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT face=Arial><FONT color=#0000ff><FONT
size=2> </FONT><A
href="http://elastix.isi.uu.nl/whatsnew_04_2.php"><FONT
size=2>http://elastix.isi.uu.nl/whatsnew_04_2.php</FONT></A></FONT></FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>If you
find any bugs or have comments on this new release, please contact us through
the mailinglist:</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT face=Arial><FONT color=#0000ff><FONT
size=2> </FONT><A href="mailto:elastix@bigr.nl"><FONT
size=2>elastix@bigr.nl</FONT></A></FONT></FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>We are
also looking for a volunteer to build MacOSX binaries for us, so we can place
them on the website.</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2 face=Arial>Enjoy
elastix!</FONT></SPAN></DIV>
<DIV><SPAN class=250084514-18082009><FONT color=#0000ff size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><FONT face=Arial><SPAN class=250084514-18082009><FONT color=#0000ff><FONT
size=2>Stefan Klein and Marius Staring<SPAN
class=343342415-18082009> </SPAN></FONT></FONT></SPAN></FONT></DIV>
<DIV><FONT face=Arial><SPAN class=250084514-18082009><FONT color=#0000ff><FONT
size=2><SPAN
class=343342415-18082009> </SPAN></FONT></FONT></SPAN></FONT></DIV></DIV></BODY></HTML>