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<p class=MsoNormal><span lang=EN-GB>Hi,<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB>I have two highly anisotropic MRI datasets (EPI
T2* and T2) that I would like to register. After having read the section
on the ITK Software Guide about how to resample an anisotropic dataset to make
it isotropic (particularly the comments that accompanied the code lines), I
started wondering about which approach to follow.<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB>My initial idea was to do this
three-dimensionally, despite the poor resolution on the z direction. Indeed,
most papers dealing with the registration of such datasets use normally 3D
rigid registration. However, the ITK Guide left me thinking whether there is
any advantage at all of doing it in 3D, since there will always be information
missing on the z-direction (even after the resampling to make the datasets
isotropic). On the other hand, slice-by-slice registration seems too little,
because after all we have several acquisitions on the third dimension.<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB>Since I am new to medical image
registration, I was wondering if someone could give some hints or further
advice about how to handle this sort of datasets. How “wrong” or
inaccurate is it to perform 3D registration with very “2D-like”
datasets? And is it very different to make both datasets isotropic and then
register them or registering them without making them isotropic?<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB>Thank you in advance,<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB>Rita<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-GB><o:p> </o:p></span></p>
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