Hello all,<br><br>I am trying to quantify the amount of tissue deformation using "before and after deformation" MR images (a series of 2D slices). However, there is a significant amount of shearing in the deformation process which from what I've read can be difficult to analyze. A previous colleague used a B-spline deformable transform/registration algorithm in ITK and employed Mattes Mutual Information, but his deformations were with much less (almost none) shearing.<br>
<br>Is there anyone that could point me towards appropriate coding for this, or suggest an alternative for measuring this deformation? <br><br>Many thanks.<br clear="all"><br>-- <br>Tim Bhatnagar<br>