FRAT

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(F)luid (R)egistration and (A)tlas (T)oolkit

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Overview FRAT provides c++ libraries and command line applications for performing fluid registration based operations on 2D and 3D images. The registration method used throughout is based on the large displacement diffeomorphic metric mapping (LDDMM) technique. We use variants of LDDMM to address the problems of time series analysis, cross-sectional atlas building, longitudinal atlas building, and geometric metamorphosis. Command Line Tools LDDMM: Fluid registration between two images. TimeSeries: Time series analysis of longitudinal data for a single subject. AtlasBuilder: Cross-sectional atlas building for a population of images. LongitudinalAtlasBuilder: Longitudinal atlas building for a population of subjects, each with a longitudinal data set. GeometricMetamorphosis: Perform registration on image pairs undergoing geometric change. FRATUtils: A colleciton of utilitiy functions for working with volumes and time seried files. Driving Applications Traumatic brain injury (TBI) diagnosis Diagnosis of tumor growth and malignancy Atlas construction for neuro-development in primates Technical Focus Vascular pattern analysis is the characterization and comparison of individuals and populations based on "spatial graphs" as representations of vascular networks. Sliding organ registration are methods for registering images of multiple organs in which the organs may have shifted, expanded, or compressed independently. Intra-operative ultrasound registration is the grand challenge of real-time transcription of pre-operative surgical plans into intra-operative ultrasound images.