FRAT

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(F)luid (R)egistration and (A)tlas (T)oolkit

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Overview FRAT provides c++ libraries and command line applications for performing fluid registration based operations on 2D and 3D images. The registration method is based on the large displacement diffeomorphic metric mapping (LDDMM) registration method and implements discretized fluid registration. This registration method is then applied to time series analysis, cross-sectional atlas building, longitudinal atlas building, and geometric metamorphosis. Command Line Tools LDDMM: Fluid registration between two images. TimeSeries: Time series analysis of longitudinal data for a single subject. AtlasBuilder: Cross-sectional atlas building for a population of images. LongitudinalAtlasBuilder: Longitudinal atlas building for a population of subjects, each with a longitudinal data set. GeometricMetamorphosis: Perform registration on image pairs undergoing geometric change. FRATUtils: A colleciton of utilitiy functions for working with volumes and time seried files. Driving Applications NeuralNav: Brain tumor resection guidance via intra-operative registration Diagnosis of retinopathy of prematurity Analysis of vascular differences within and between populations to identify focal (e.g., stroke) and diffuse (e.g., schizophrenia) diseases. Vascular atlas formation Radiofrequency ablation guidance via intra-operative registration of pre-op CT with intra-op Ultrasound Quantifying tumor micro-environments (with UNC BME Dept.) http://www.ii.uib.no/vis/publications/publication/2010/birkeland10USpainting Technical Focus Vascular pattern analysis is the characterization and comparison of individuals and populations based on "spatial graphs" as representations of vascular networks. Sliding organ registration are methods for registering images of multiple organs in which the organs may have shifted, expanded, or compressed independently. Intra-operative ultrasound registration is the grand challenge of real-time transcription of pre-operative surgical plans into intra-operative ultrasound images.