TubeTK

Overview

TubeTK is being developed to host algorithms for applications involving images of tubes. By focusing on the geometry of tubes we can accomplish grand challenges in image analysis in a subset of significant cases.

Features

• Centerline vascular segmentation
• Vascular atlas formation
• Vascular network to image registration
• Organ segmentation
• Vascular-ness measures
• Multi-modality support

Driving Applications

• NeuralNav: Brain tumor resection guidance via intra-operative registration
• Diagnosis of retinopathy of prematurity
• Analysis of vascular differences within and between populations to identify focal (e.g., stroke) and diffuse (e.g., schizophrenia) diseases.
• Vascular atlas formation
• Radiofrequency ablation guidance via intra-operative registration of pre-op CT with intra-op Ultrasound
• Quantifying tumor micro-environments (with UNC BME Dept.)

Technical Focus

• Vascular pattern analysis is the characterization and comparison of individuals and populations based on "spatial graphs" as representations of vascular networks.
• Sliding organ registration are methods for registering images of multiple organs in which the organs may have shifted, expanded, or compressed independently.
• Intra-operative ultrasound registration is the grand challenge of real-time transcription of pre-operative surgical plans into intra-operative ultrasound images.

Developers

• Build and development instructions
• Events and meetings

Users

• TubeTK with Slicer
• TubeTK with ImageJ
• Image gallery
• Users Documentation

Data and Publications

• Data and Publications

Support

• Users and Developers email lists (email lists are closed during Beta development)

Team Members and Collaborators

• Kitware
• Brigham and Women's Hospital
• Duke University
• BrainLAB

Funding

The development of TubeTK is being funded, in part, by the following grants

1. NIH/NIBIB sponsored "National Alliance of Medical Image Computing" (NA-MIC, PI: Kikinis) project
   • 1U54EB005149-01
   • http://www.na-mic.org
2. DARPA sponsored "Trust in Integrated Circuits" (EXPOSE, PI: Bajura) program
   • USC/ISI Team
   • http://www.darpa.mil/MTO/Programs/trust/index.html
3. NIH/NCI sponsored "Image Registration for Ultrasound-Based Neurosurgical Navigation" (NeuralNav, PI: Aylward, Wells)
   • 1R01CA138419-01
   • http://public.kitware.com/Wiki/NeuralNav

License

• TubeTK is distributed under the Apache 2.0 license.
  • You are free to use, modify, and redistribute TubeTK for non-commercial and commercial uses.

Thank You!

TubeTK is builds upon and contributes back to a variety of open-source efforts, including the following:

ITK	Slicer	CTK
CMake	CDash	MIDAS